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This work was supported by the National Natural Science Foundation of China (U23A20501, 82404816), the key research and development plan projects of Heilongjiang Province (2022ZX02C04), the Guangdong Basic and Applied Basic Research Found Project (2023A1515110703), the Traditional Chinese Medicine Bureau Of Guangdong Province (20254061), the State Key Laboratory of Dampness Syndrome of Chinese Medicine (SZ2021ZZ49, SZ2022KF16), the Second Affiliated Hospital of Guangzhou University of Chinese Medicine(YN2024GZRPY017)