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The study also found that after semaglutide intervention, the food intake of obese mice decreased significantly, achieved by regulating appetite-related factors in the hypothalamus, indicating that semaglutide could penetrate the blood-brain barrier to reach the hypothalamus, brainstem, and arcuate nucleus through peripheral administration (Martins et al., 2022)

DOI: 10.1038/ejcn.2015.191

Xu Z, Wu C, Sun-Waterhouse D, Zhao T, Waterhouse GIN, Zhao M

This is also a period when food quality can become more important

IGF-1 + SARMs (e.g., RAD-140, LGD-4033) A mild post-cycle protocol is recommended: DHEA 100 mg/day for 4 weeks ZMT Hormonal support and cortisol regulation Optional: Over-the-counter aromatase inhibitors if experiencing estrogen-related side effects For more on hormonal changes when stopping support compounds, read What Happens When You Stop Taking DHEA