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luminal glucose + SSTR5a, 190 37 fmol/min P = 0.0045) (Figure 1, G and H)

The GIP/GLP-1-receptor agonist tirzepatide was approved for the treatment of T2D by the Food and Drug Administration (FDA) in the USA for once-weekly subcutaneous injections in May 2022 and has just received a positive opinion from the European Medicines Agency (EMA)

This can harm the gut lining, kill healthy bacteria, and make it harder to absorb nutrients like folate and B vitamins

Therefore, the protective role of vitamin D in protecting against neurodegenerative diseases in humans may be justified (103)