In a pre- and postnatal development study in pregnant cynomolgus monkeys, subcutaneous doses of 0.015, 0.075 and 0.15 mg/kg twice weekly (1.3-, 6.4- and 14-fold the MRHD) were administered from Gestation Day 16 to 140
Consequently, IL-6/STAT3 signaling is correlated with tumor progression, invasion, and immune evasion [174]
PRECAUTIONS: Vitamin B12 deficiency that is allowed to progress for longer than 3 months may produce permanent degenerative lesions of the spinal cord
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[29] Maruyama T, Maruyama N, Higuchi T, et al