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These centres are created by electron-withdrawing groups

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EHMF exhibited potent anti-inflammatory effects, notably reducing the expression of pro-inflammatory cytokines like TNF-, IL-6, and EGFR, which are typically upregulated in response to UV exposure and play a crucial role in accelerating skin aging and exacerbating inflammatory responses ( in vivo experiments in mice and in vitro studies using HaCaT cells, where EHMF (0.1250.5 mg/mL) effectively prevented UV-induced cell death and demonstrated anti-inflammatory properties

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