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Further, the model spectra included a macromolecule spectrum acquired from the occipital cortex of 5 volunteers, using an inversion recovery sequence (TR = 3 s, TE = 11 ms, inversion time TI = 0.685 s)

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According to Ghiyam, researchers were particularly concerned about uncontrolled darkening of existing moles and other pigmentation changes, which contributed to the decision not to approve the drug

PMC 3650358