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Myofibroblasts are the primary producers of collagen in tissue fibrosis 67,68 and play a role in tissue stiffness and the development of skin and joint contractures in SSc patients

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I tell patients early on that significant weight loss can temporarily unmask laxity in the lower face, neck, upper arms, and abdomen, and that hair shedding can occur for several months

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The label goes further: tolerance to the appetite effect usually develops within a few weeks, and when that happens the instruction is to stop the medication, not increase the dose