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Long-chain acyl-CoA then binds to free carnitine in the mitochondrial outer membrane under the catalysis of carnitine palmitoyl transferase 1 (CPT1) to form LCACs
Initial dosage
Thus, although some of the damage in this experimental model of colitis reflects a direct erosive effect of TNBS and ethanol, their combined administration to rats reflects the in vivo operation of the damaging mechanisms elicited by TNBS, namely GSH depletion and ROS generation, indicating that ethanol facilitates the access of TNBS to the cell interior ensuring TNBS-induced GSH depletion and ROS generation
Growth hormone & IGF research, 19(5), 426431
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