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The observed GLP-1R/GIPR dual activity is particularly similar to that of tirzepatide, a clinically approved dual incretin agonist (Jastreboff A et al., 2022)
Related to vasodilation
More advanced non-peptidic agonists have been identified with distinct binding modes and activation mechanisms
Kaess BM, Pedley A, Massaro JM, Murabito J, Hoffmann U, Fox CS
If long-term storage is needed for reconstituted solution, freeze single-use aliquots rather than the same vial over and over
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