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Absolute contraindications include: Active malignancy of any kind (GH and IGF-1 are growth-promoting signals) Active diabetic retinopathy (IGF-1 may worsen retinal vascularity) Pregnancy or breastfeeding Known hypersensitivity to any component of the formulation Pituitary tumours or untreated hypothalamic disease Relative contraindications requiring careful evaluation include pre-existing insulin resistance, type 2 diabetes, uncontrolled cardiovascular disease, and sleep apnoea (GH elevation can worsen upper airway tone in susceptible individuals)
For patients with autoimmune thyroid disease, this distinction matters more than most clinicians recognize
Because protein needs vary by individual, Voyer says protein goals should be based on factors such as body composition, activity level and estimated calorie expenditure during weight loss
Second, Gln deprivation sensitizes cancer cells to apoptotic stimuli
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