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The primary question emerging from the extant evidence is: why did the pronounced neuroprotective effects observed in laboratory settings and the significant risk-reduction signals in population studies not translate into a therapeutic advantage for patients with early Alzheimers disease in the EVOKE trial

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Our data also suggest that Sp, in combination increases the therapeutic potency of L-DOPA by mitigating its chronic toxicity

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*Correspondence: Gholamreza Askari, [email protected]