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All values were normalized to fully oxidized (AT-2-treated) and fully reduced (DTT-treated) roGFP2 with the following equation [1]: with R ox being the 405/488 ratio of oxidized (AT2-treated) and R red of reduced (DTT-treated) roGFP2 respectively

Patients on any oral antihyperglycemic agent in monotherapy (N=212) or on a PPAR agent in combination therapy (N=106) or not on an antihyperglycemic agent (off therapy for at least 8 weeks, N=34) were switched to monotherapy with pioglitazone (at a dose of 30-45 mg per day), and completed a run-in period of approximately 12 weeks in duration