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Restricting cysteine, depleting GSH, or inhibiting GPX4 can increase phospholipid peroxidation in responsive cells, but sensitivity also depends on lipid composition, iron metabolism, parallel antioxidant systems, and tissue context (Jiang et al., 2021)
The proportion of time spent in open areas, the number of open-section entries (where the entire body has crossed into the open area), and the distance that each mouse had travelled were determined
Early-phase human trials are small, well-controlled studies centered on safety, reproductive hormones, and surrogate markers such as ovarian reserve tests and sperm parameters ahead of any efficacy trials
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It is especially critical in the detoxification of harmful substances and the neutralization of free radicals, making it one of the primary defense mechanisms against oxidative stress
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