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Now that millions of people are taking these medications far beyond the scope of clinical trials researchers are beginning to understand why

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Pathogenic tau can seed synaptically connected cells and lead to the stimulation and aggregation of natively folded tau in naive cells, leading to further progression of the disease ( A laboratory study conducted on transgenic mice expressing human non-mutant tau was used to assess the impact of the post-translational hyper-phosphorylation of tau on the central and peripheral nervous system after a period of 3 and 6 months (Marquez et al., 2021)