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CYP4F8 is present in epithelial linings and catalyzes the (1)-hydroxylation of prostaglandin H 2 (PGH 2 )

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doi: 10.1016/j.brainres.2018.03.015 165 MiriSYeoJAbubakerSHammamiR

TB-500 (Thymosin Beta-4 fragment) acts on actin sequestration and cell migration the upstream cytoskeletal pathway underlying re-epithelialisation, fibroblast motility, cardiac repair and muscle satellite-cell activation

In multiple pathological settings, affected cells are not distributed randomly, but instead form contiguous zones of degeneration, synchronized tubular epithelial loss, aligned myofiber injury, or expanding fronts of tissue damage, patterns that are difficult to reconcile with strictly cell-autonomous execution