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Nowadays, LBVS has proved to become one of the primary tools for drug repurposing against AD, targeting key proteins that are associated with AD such as A-protein, GSK-3, and Monoamine Oxidase B (MAO-B) (Speck-Planche et al., 2012)
The protective effect was closely linked to SMR5 induction, which down-regulates cell-cycle activators while upregulating water deprivation and detoxification genes, leading to enhanced root suberization and reduced nonstomatal transpiration ( In Prunus persica (peach), -CCA treatment significantly enhanced drought tolerance by alleviating leaf wilting and promoting rapid recovery after rewatering (Zhu et al., 2023)
Drugs 79, 13551361
The key differences are in selectivity how much they activate other pathways beyond GH release
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