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The CBP lysine acetyltransferase is a well-recognized, direct NRF2 binding partner (Tonelli et al, 2018), contributing to NRF2 transcriptional activity at reporter genes (Katoh et al, 2001) and responsible for acetylating NRF2 itself (Sun et al, 2009)

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Unlike anti-inflammatory drugs that can impair healing by suppressing necessary processes, the combination modulates inflammation appropriately reducing the excess that causes tissue damage while preserving whats needed for debris clearance and the start of healing