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The most common side effects for patients taking a GLP-1 are gastrointestinal issues

Detailed single-drug findings are provided in Supplementary Materials 2

up to 1.8%) and body weight compared with placebo and several active treatments, including sitagliptin, exenatide (extended-release), dulaglutide, and insulin glargine.In the SUSTAIN 6 trial, semaglutide also demonstrated CV safety and significantly reduced MACE compared with placebo, confirming its noninferiority while suggesting potential CV protection.[9] 5