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Gene expression analysis showed upregulation of survival pathways (Egr1, Akt1, Kras, Src, Foxo, Srf, VEGFR2, NOS1, NOS3) and downregulation of inflammatory mediators (NOS2, NFB)

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Not only does significant weight loss itself contribute to a deflated bottom when the subcutaneous fat under the skin gets smaller, but Amir Ghaznavi, a board-certified plastic surgeon in Herndon, Virginia, tells the Daily Beast that GLP-1s have been shown to decrease the amount of Type I collagen in the skin, which causes a sagging effect

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