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- Phase 2: Focuses on the drug's effectiveness and further evaluates its safety in a larger group of individuals with the targeted condition

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Rugged skin seems lifeless and worn out because dead cells accumulate and scatter light

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A later dosage change can therefore affect an individual's side-effect timeline

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As the body adjusts and weight loss stabilizes, normal hair growth often returns, although it can take several months to see improvement

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A systematic review and meta-analysis of 49 studies, published in Frontiers in Nutrition in 2022, found that "although (berberine) may affect weight, it does not have a statistically significant and considerable effect" on body mass index, resulting in about a quarter point reduction in BMI

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