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doi: 10.1016/j.regpep.2013.03.026

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Among GLP-1 RA users in the final study sample, the proportion of semaglutide users increased from 5.1% in 2018 to 63% in 2023 ( Meanwhile, from 2018 to 2023, the proportion of diabetic GLP-1 RA users decreased from 89% to 66%, respectively, and those without a diagnosis of diabetes (groups 3 and 4) tripled their share from 11% to 34% ( Among group 3 (without diabetes and without obesity/overweight), there was a steady increase in off-label semaglutide (Ozempic) prescribing from 3.6% to 30%, and off-label semaglutide (Wegovy) increased to 38% drug share in 2023

Consequently, in the early stages of Parkinson's disease, the predominant therapeutic approach involves dopamine supplementation, often through the prescription of L-dopa or dopamine agonists, aimed at providing temporary relief from the disease's symptoms [45]

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