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The Semaglutide Treatment Effect in People with Obesity and Heart Failure with Preserved Ejection Fraction and Diabetes Mellitus (STEP-HFpEF DM) trial demonstrated that semaglutide significantly reduced body weight and improved HF-related symptoms and physical limitations in people with obesity-related HF with preserved ejection fraction and type 2 diabetes mellitus [93]
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Andersen CY et al
[cite_start]Intranasal administration specifically bypasses first-pass hepatic metabolism and the blood-brain barrier (BBB) via olfactory and trigeminal nerve pathways[cite: 396]
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