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GLP-1 receptor agonists (GLP-1 RAs), primarily developed for their metabolic effects 68 , demonstrated neuroprotective activity in preclinical models over two decades ago 9 with subsequent studies revealing anti-inflammatory effects in both central and peripheral tissues 10

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This led to further double-blinded, randomized, placebo-controlled trials examining the effects of semaglutide and tirzepatide in patients with obesity, but who did not have type 2 diabetes

PhoA is only active upon formation of intramolecular disulfide bonds essential for correct protein folding