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We found that the SAM/SAH ratio, known as the methylation index because it indicates the methylation capacity of an organism 36 , was significantly increased during in vivo reprogramming (Extended Data Fig
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No significant differences between treatment groups were observed using the Chao1 richness estimate 42 , which accounts for ASV rareness in the richness measure (Supplementary Fig
doi:10.1136/bmjopen-2014-006964
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