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Yet, de novo choline synthesis in humans is not sufficient to meet their metabolic needs such that healthy humans fed choline-deficient diets develop fatty liver, liver damage, and/or muscle damage (see Deficiency)

The ACHIEVE-3 study enrolled 1,698 adults with type 2 diabetes inadequately controlled on metformin and compared two doses of Foundayo with approved doses of oral semaglutide over 52 weeks. At the highest dose comparison, Foundayo 17.2 mg reduced A1C by an average of 2.2% from a baseline of 8.3%, compared with a 1.4% reduction for oral semaglutide 14 mg. The difference represented a 57.1% greater relative reduction in A1C. "ACHIEVE-3 provides the first head-to-head data on oral GLP-1s in type 2 diabetes, with orforglipron showing greater A1C and weight reductions than oral semaglutide." Julio Rosenstock, MD The treatment also produced greater weight loss