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Clinical Guidance: If you are losing weight on a GLP-1, you should work closely with your GP to have your TSH and Free T4 levels checked every 812 weeks

Tirzepatide is an acylated peptide engineered to activate the GIP and GLP-1 receptors, key mediators of insulin secretion that are also expressed in regions of the brain that regulate food intake

In practice, a combination of these approaches is used

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General eligibility criteria per brand disclosure include BMI 30, or BMI 27 with at least one qualifying comorbidity