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Research presented at the 2025 American Academy of Orthopaedic Surgeons meeting found GLP-1 users had approximately 30% higher rates of osteoporosis compared to non-users, and a 2024 phase 2 trial published in eClinicalMedicine showed increased bone resorption markers and lower bone mass at the spine and hip in the semaglutide group versus placebo after 52 weeks

Stillbirth rates are also slightly elevated at 0.6-1.0% compared to 0.4-0.6% in women without these conditions

That means a real evaluation up front, a dose set by a prescriber, and someone accountable if a side effect shows up the safeguards that keep glutathione on the well-tolerated end of the spectrum

When Things Get More Serious The bigger concerns are rare, but they're worth knowing about

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