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Losing weight is an emotional, physical, and personal challenge that goes beyond just diet and exercise For many, it's tied to medical conditions that make traditional methods less effective

Johns Wort acts similarly to several antidepressants, but is less effective, says Chris Pagnani, MD, the founder and medical director of Rittenhouse Psychiatric Associates in Philadelphia

The GIP component may also contribute to potentially milder gastrointestinal side effects compared to GLP-1-only medications

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