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Women of childbearing potential should discuss contraception, as tirzepatide can decrease exposure to oral contraceptives, requiring backup contraception for 4 weeks after initiation and after each dose increase

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In controlled research models, NNMT inhibition by 5-Amino-1MQ may increase intracellular NAD+ levels and SAM availability, making the compound relevant to investigations involving sirtuin activity, methylation capacity, and adipocyte differentiation