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MindMeds Phase 2b study, MMED008, met its primary and key secondary endpoints and demonstrated rapid, clinically meaningful, and statistically significant improvements on the Hamilton Anxiety Rating Scale (HAM-A) at Week 4 and Week 12, with a 65% clinical response rate and 48% clinical remission rate sustained to Week 12 in the MM120 100 g cohort

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PVH: Para-ventricular hypothalamus

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He said: It is well established that better mental health tends to follow from better physical health and since the 1880s we have known that diabetes is associated with depression, although I think its unlikely that using GLP-1R agonists alone as treatments for depression or anxiety will work. Prof Eduard Vieta, a professor of psychiatry at the University of Barcelona and editor in chief of the European College of Neuropsychopharmacology journal, said: From a clinical perspective, these findings are reassuring regarding the psychiatric safety of GLP-1 receptor agonists and suggest a potential role not only in preventing worsening but also, possibly, in improving mental health outcomes