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Also, do not take with certain strong CYP3A4 inhibitors, such as Ritonavir and Ketoconazole, as they can boost Orforglipron blood levels and increase the risk of side effects
Dev Dyn 2012;241:1183-1191
Cagrilintide is engineered around that problem: it is a modified, lipidated peptide that acts as a dual amylin and calcitonin receptor agonist and is stable enough for once-weekly subcutaneous dosing
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