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Copper uptake is also a crucial factor

It exerts its effects primarily within the tissue microenvironment at or near the site of injury

This mechanistic diversity enables applications across a broad spectrum of medical conditions and continues to expand as new targets and approaches are identified

10.1016/j.thromres.2011.07.035 135 StupnisekM.KokotA.DrmicD.Hrelec PatrljM.Zenko SeverA.KolencD.et al (2015)

Further analysis revealed that ABC2 was amplified and overexpressed in an estramustine (EM)-resistant human ovarian carcinoma cell line, and antisense-mediated downregulation of ABC2 expression sensitized the cell line to EM