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In addition, their impact on gastric motility has raised perioperative concerns, particularly related to delayed gastric emptying, which increases the risk of vomiting and aspiration during induction of general anesthesia
188 These findings suggest that CTSB inhibitors may act on both acinar cells and macrophage-driven inflammation and that dual-targeted strategies focusing on CTSB and its downstream signaling (e.g., NF-B) may offer a more comprehensive approach to treatment
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