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Unlike semaglutide, which targets only the GLP-1 receptor, tirzepatide is a dual-action medication that activates both GLP-1 and GIP (glucose-dependent insulinotropic polypeptide) receptors

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Although both dysregulated hepatic glutathione homeostasis and TNF overproduction are critically involved in the development of NAFLD, whether they can be synergistically implicated in hepatocyte death remains to be clearly defined