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Potential Benefits and Risks of Microdosing GLP-1 Microdosing GLP-1 is proposed to reduce dose-dependent gastrointestinal side effects such as nausea and vomiting, but lacks randomised controlled trial evidence for efficacy or safety

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Long-term success depends not only on individual motivation but also on the responsiveness of the surrounding social environment, which plays a critical role in supporting sustained dietary and lifestyle changes [16]

GLP-1 receptor activation inhibits the activation of hepatic Kupffer cells and infiltrating macrophages, leading to decreased production of pro-inflammatory cytokines such as TNF- and IL-1, thereby attenuating hepatic inflammation (44)