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Upon ligand binding that leads to GIP receptor activation, the receptor primarily couples to the G s subfamily

Under the first phase of the ongoing two part study, the drug demonstrated "statistically significant improvement in liver fibrosis and resolution of steatohepatitis compared to placebo." In August 2025, the company received final approval to market the therapy for the additional indication in the US, followed by a conditional approval in Canada in December

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doi: 10.1016/j.intimp.2025.114190 131 QiyanZZhangXGuoJWangYJiangYLiSet al

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