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While clinical trials show these medications can lead to a 5%18% reduction in body weight, failing to consume at least 60 grams of protein daily could result in 20%38% of that weight loss coming from muscle

When gut bacteria ferment fibre in the colon, they produce short-chain fatty acids (SCFAs) such as butyrate, propionate, and acetate, which directly stimulate L-cells to release GLP-1

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Chen Z, Agnew JL, Cohen JD, He P, Shan L, Sheen J, Kunkel BN

Early data looks promising, but real-world use will determine whether the triple-action approach truly outperforms dual agonists