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New fluorescent method for the histochemical detection of dipeptidyl peptidase IV using glycyl-l-prolyl-2-anthraquinonyl hydrazide as substrate

Tirzepatide, the active ingredient in Mounjaro, produced high average results in the SURMOUNT-1 randomised controlled trial, with participants losing around 2022% of their body weight on average over 72 weeks

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doi:10.2337/db18-0543.

In a double-blind study of n=16 chronic insomniac patients, intravenous DSIP at 25 nmol/kg over 3 nights was associated with higher sleep efficiency and shorter sleep latency (the time it takes to fall asleep) compared with placebo, but the effects were described as weak [4]