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While GLP-1, and to a slightly lesser degree exendin-4, form very stable interactions with R190 2.60 , Y152 1.47 , Y241 3.41 and E364 6.53 , exendin-P5, and in particular, oxyntomodulin, form much more transient interactions with these key residues

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Botulinum toxin, a potent inhibitor of neuromuscular transmission, has been reported to improve emptying and symptoms for several months in DGp and idiopathic gastroparesis in several open label studies [128]