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This is a consequence of senescent cells being primed for apoptosis and upregulating antiapoptotic mechanisms to prevent intrinsic 24 and extrinsic 26 apoptosis, which makes them vulnerable to the inhibition of these protective mechanisms
10.1016/j.amjcard.2007.05.022 209
Appetite effects appeared earlier than the maximal weight loss because they began at sub-maintenance doses
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