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Positive outcomes emerged, but further studies are needed in order to validate its clinical efficacy (Warita et al., 2019)

It may also have protective effects on how fat is stored and utilized, particularly in adipose tissue

Deliberate structural modification has been applied to overcome the short half-lives of native GIP and GLP-1 (Fig

GABA, the main inhibitory neurotransmitter, supports sleep, mood, blood pressure, pain perception, and precise nerve function.27 28 Studies show that mice without hepatic GSH synthesis die within a month, highlighting the importance of GSH in critical processes like digestion, DNA replication, respiration, and muscle and nerve function

However, effects on advanced fibrosis remain under investigation, with phase 2 trials of semaglutide showing MASH resolution without confirmed fibrosis improvement