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Heng TS, Painter MW, Immunological Genome Project C (2008) The Immunological Genome Project: networks of gene expression in immune cells
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doi: 10.1097/00054725-200405000-00015 199
Chemical modifications such as lipidation (first applied therapeutically to insulin in the 1990s), PEGylation (established as a platform technology in the early 2000s), and reversible albumin binding have transformed peptides from short-lived signaling molecules into durable therapeutics suitable for weekly or even monthly administration (Langer, 1998
5-HT2A/2C receptor blockade regulates progenitor cell proliferation in the adult rat hippocampus
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