Food and Drug Administration (FDA) approved L-glutamine oral powder, marketed as Endari , to reduce severe complications of sickle cell disease in people aged five years and older with the disorder
These include persistent abdominal pain, vomiting that contains blood or material resembling coffee grounds, severe dizziness, shortness of breath, or signs of allergic reaction such as facial swelling or hives
That means no regulatory body has evaluated it for safety or efficacy at these doses
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Moreover, in a 2025 systematic review 2 by Raheem et al