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Having depression is not necessarily a contraindication to GLP-1 treatment, but it requires careful consideration and monitoring
In a 2023 Phase 2 trial published in the New England Journal of Medicine (Jastreboff et al.), retatrutide produced 22.8% to 24.2% mean weight loss at 48 weeks at the higher doses (8 to 12 mg)
Mounjaro has been shown to produce an average 15.7% reduction in body weight, with almost a third of participants experiencing a reduction exceeding 20%
CJC-1295 and Sermorelin are GHRH analogs, meaning they mimic growth hormonereleasing hormone signaling at the pituitary
Summary: You can stop Trulicity cold turkey without withdrawal symptoms, but doing so without medical guidance risks loss of blood glucose control and diabetes complications
