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Low Starting Amount Amount per injection: 2.5 mg 50 units (0.50 mL) on a U-100 insulin syringe Frequency: Once daily, under the skin (subcutaneous) Cycle length: One 5 mg vial = 2 days at the starting amount Sources: [1] Selective small-molecule inhibitors of NNMT reverse high-fat-diet-induced obesity in mice PubMed

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Clinical trials commonly start with 1 mg weekly and gradually increase the dose to higher levels such as 4 mg, 8 mg, or even 12 mg depending on the study protocol