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Within 12 months of stopping, 27% had switched to a different medication, 20% restarted their original medication, 14% continued with lifestyle modification supported by professionals, and less than 1% pursued bariatric surgery
Back Brown, M, Goldstein, J, Podolsky, DK, et al (1 Sept 2020) 'In Memoriam: Dr
pairing with metformin targets complementary nutrient-sensing pathways
GLP-1 medications have long half-lives
However, research also highlights the potential for synergy between GLP-1 and lifestyle changes
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![Mechanism of action of GLP-1 [25]](https://www.researchgate.net/profile/Asfandyar-Sheikh/publication/256289222/figure/fig1/AS:614177232142337@1523442671231/Mechanism-of-action-of-GLP-1-25.png)
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