injection site hurts after semaglutide Where to Inject Semaglutide: Optimal Sites for Maximum Efficacy Stomach, Thigh, or Arm: What's

(Source: ASMBS, June 2025) A 2026 network meta-analysis of randomized controlled trials (30 trials, 20,015 patients) found metabolic/bariatric surgery achieved significantly greater reductions than GLP-1 receptor agonists in total weight loss (10.3 percentage points), BMI (4.5 kg/m), body weight (11.7 kg), waist circumference (12.6 cm), and HbA1c (0.5%) at under 104 weeks

This is particularly relevant for women of reproductive age with lipoedema

However, you should contact your GP for persistent symptoms, NHS 111 for urgent concerns, or attend A&E if you experience severe, persistent vomiting, signs of dehydration (dark urine, dizziness, reduced urination), severe abdominal pain (especially if radiating to the back), or symptoms of gallbladder problems (severe upper right abdominal pain, fever, yellowing of skin/eyes)

Maybe things improved a little at first, but you're still waking up drenched in sweat twice a night

[1] Liraglutide is also available under NICE TA664 criteria