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Myocardial changes encompass myocyte necrosis, apoptosis, and autophagy, as well as myocardial fibrosis driven by fibroblast proliferation, MMP activation, and inflammation 28
GLUTATHIONE IMPORT TO MITOCHONDRIA As indicated above, despite the fact that the concentration of mGSH is high, GSH is not synthesized de novo in the mitochondrial matrix, as this organelle lacks the enzymes required for GSH synthesis
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