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Although metformin is known as an AMPK activator 15 , it neither induces beta cell apoptosis nor ameliorates MG-induced beta cell apoptosis

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L-Carnitine alleviates hepatic and renal mitochondrial-dependent apoptotic progression induced by letrozole in female rats through modulation of Nrf-2, cyt C and CASP-3 signaling

Add a small portion of a complex carbohydrate like sweet potatoes

There are some reports of acute pancreatitis, including fatal and non-fatal hemorrhagic or necrotizing variants but it remains unproven till now and not observed in post market surveillance