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Glucagon and GLP-1 are homologous peptides that activate homologous receptors and moreover glucagon cross-reacts on GLP-1R with full efficacy but reduced potency compared to GLP-1 37,38
And indeed that is the case: Those started on GLP-1s were 36% more likely to lose 5 points of BMI and 25% more likely to lose 10 points
This context helps your provider differentiate adaptation from an adverse signal
Can you pause, switch formulations, or cancel without financial penalty
Thats why neither of these physicians recommend Ozempic or anything similar for people trying to get pregnant
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